Coagulation and Hemostatic Effects of Dextran and Other Macromolecules.
Abstract
A major problem associated with the use of several colloids as plasma substitutes for blood replacement, blood volume expansion, resuscitory and other therapeutic purposes, is hemostatic failure in a certain percentage of human as well as animal recipients, first documented for dextran (D) by Crosby et al (1). This serious disadvantage has been similarly observed with several related and non-related macromolecular agents -- hydroxyethyl starch (HES), polyvinyl pyrrolidone (PVP), acacia, some of gelatin -- and, indeed, with large volumes of bank blood. The cause(s) of the hemostatic defect remains obscure. The objective was helping elucidate the underlying cause of this hemostatic failure. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 06, 1972
- Accession Number
- AD0741381
Entities
People
- Benjamin Alexander
Organizations
- New York Blood Center