Passive Suppression Characteristics of a Rabbit Antihuman Lymphocyte Serum.
Abstract
The passive suppression characteristics of a rabbit antihuman lymphocyte serum of high titer anti-B.L., resulting from prolonged immunization with purified lymphocytes from a single individual, B.L., were studied. This antiserum had been shown to contain antibodies directed primarily against a human species lymphocyte antigen; however, the antibodies appeared to have a broadened specificity which cross-reacted with individual-specific antigens. Antibodies directed solely toward individual-specific human lymphoid antigens could not be detected. It was found that anti-B.L. could suppress not only the immune response to B.L. lymphocytes, but similarly suppressed the immune response to non-B.L. lymphocytes from each of two other individuals unrelated to B.L., and to each other. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 1972
- Accession Number
- AD0741817
Entities
People
- C. Elliott Bell Jr.
Organizations
- United States Army Medical Research Laboratory