Characterization of Tissue Ingrowth Into Porous Bioceramics
Abstract
A study of the tissue compatibility of the aluminum oxide implant material under different stress conditions in rabbits was performed over 4- and 8-week implantation periods. The specific objectives was to examine endosteal bone ingrowth into aluminum oxide cone-shaped stump plugs in amputated tibiae, while additional peelet-shaped implants in the tibiae and femur of rabbits with amputated and non-amputated limbs were studied to determine: (a) if the degree of loading placed on the amputated limb was sufficient to promote bone activity, (b) the degree of inertness and/or toxicity of the aluminum oxide implants, and (c) a possible cause of bone spurs. The results of the radiographic, histologic and microradiographic analyses of the in vivo implants demonstrated that there was little mineralized bone ingrowth into the cone-shaped aluminum oxide implants in the amputated tibiae. The study also showed that the aluminum oxide pellet implants in the tibiae and femur of the non-amputated limbs demonstrated excellent mineralized bone ingrowth into surface and internal pores.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1972
- Accession Number
- AD0742445
Entities
People
- Barry W. Sauer
- Jerome J. Klawitter
- Joel R. Matthews
- Samuel F. Hulbert
Organizations
- Clemson University