The Development of L Phase Variants of 'Neisseria meningitidis and their Pathogenicity in Experimental Animals.
Abstract
The frequency of transformation to L forms among 119 isolates of Neisseria meningitidis was found to be greatest in strains of serotype Boshard (Y). Sixty per cent of Boshard isolates showed a rate of transformation of 1 L form/10 to the 6th power diplococci, an incidence characteristic of reverted L form strains. Comparison of isolates from blood, spinal fluid and nasopharynx demonstrated that strains cultured from blood, particularly from patients without meningitis, had the highest potential for L form transformation. L form transformation has been demonstrated among 39 of 45 fresh clinical isolates of N. gonorrhoeae including direct isolation of wall-deficient gonococci from cutaneous lesions. The rate of transformation was much higher than that found for meningococcal strains, with the greatest frequency occurring among cervical isolates. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 18, 1972
- Accession Number
- AD0744052
Entities
People
- Josephine A. Morello
- Marjorie A. Bohnhoff
Organizations
- University of Chicago