A Sequential Ultrastructural Study of the Effects of an Intravenous Lipid Emulsion,
Abstract
Rabbits received 20cc/kg of intravenous lipid emulsion and were terminated from 2 hours to 8 weeks post-injection. Pigment became prominent at 6 days and was still present in liver and spleen at 8 weeks. Lipid was incorporated into macrophages in spleens at 2 hours by endocytosis. By 6 days this lipid was surrounded by pigment. The pigment was morphologically identical to secondary lysosomes. These results suggest that this lipid emulsion once incorporated into lysosomes of liver and spleen is stored there. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1972
- Accession Number
- AD0744455
Entities
People
- Lloyd D. Jones
- Marshall B. Bischoff
- Phillip L. Senger
- Richard S. Demaree Jr.