Platelet Aggregation Produced by Collagenolysis Product Peptides,

Abstract

Saline solutions of about 1 microgram of each of seven of the eight collagen peptides released by the action of cutaneous collagenase upon soluble collagen were capable of affecting the aggregation of platelets. Thus, at least two important cellular responses to injury (i.e., PMN infiltration and platelet aggregation) can be demonstrated to be produced by the products of collagenolysis. These findings on platelet aggregation reinforce the relative importance of collagenolysis product peptides in the overall process of inflammation.

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1972
Accession Number
AD0744967

Entities

People

  • Chuan‐Chieh Chang
  • J. Houck

Tags

DTIC Thesaurus Topics

  • Collagen
  • Cooperation
  • Dermatologic Agents
  • Inflammation
  • Saline Solution

Fields of Study

  • Biology
  • Computer science

Readers

  • Analytical Chemistry
  • Immunology and Pathology