Preservation of Myocardiac Function during Cross Circulation in Terminal Endotoxin Shock
Abstract
Cross-circulation between normal isolated hearts and dogs in terminal shock 18-21 hours after administration of endotoxin was performed for a period of 3 hours. Of 22 dogs injected with endotoxin, only 9 survived long enough to be studied and 2 died during the study. The results were compared to 4 normal control dogs. Isometric cardiac performance measured by intraventricular balloon distention was not impaired in the endotoxin group which showed consistently better length-tension curves and pressure work than control dogs. No alteration in force-velocity curves was noted in either group. Increases in both oxygen uptake and pressure work in the endotoxin group resulted in no change in calculated myocardial efficiency, both effects presumably a result of increased circulating catecholamines. Results fail to show any deleterious effect on a normal heart perfused with blood from a dog in terminal shock and do not substantiate a primary role for the reported myocardial depressant factor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 16, 1972
- Accession Number
- AD0746178
Entities
People
- James R. Mccurdy
- Lazar J. Greenfield
- Lerner B. Hinshaw
- Ronald C. Elkins
Organizations
- University of Oklahoma