Effects of Monomethylhydrazine (MMH) on Evoked Cerebral Neuroelectric Responses

Abstract

Studies of the effects of monomethylhydrazine (MMH) on the cerebral neuroelectric evoked response in the unanesthetized cat revealed that convulsive doses of this compound consistently produced a large increase in the primary negative response of the somatic sensory cortex which progressively changed with time and approached peak levels starting approximately 1 hour before seizure onset. Delay of seizures with neuromuscular paralysis was observed also. The possible significance of this finding in relation to mechanism of action in the nervous system was explored. These results obtained with MMH are consistent with those previously reported for unsymmetrical dimethylhydrazine (UDMH). As herein reported, the evoked response changes are similar to results obtained with the convulsant agent Metrazol, suggesting that these response changes may be a useful index of impending seizure in a variety of toxic and clinical conditions.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1972
Accession Number
AD0746302

Entities

People

  • Kenneth C. Back
  • M. B. Sterman
  • M. D. Fairchild
  • Thomas Allison
  • W. R. Goff

Organizations

  • University of California, Los Angeles

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Anesthesia
  • Biomedical Research
  • California
  • Central Nervous System
  • Cerebral Cortex
  • Classification
  • Contracts
  • Epilepsy
  • Government Procurement
  • Health Services
  • Hospitals
  • Nervous System
  • Security
  • Seizures
  • Universities

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neuroscience
  • Toxicology/Environmental Toxicology
  • Underwater engineering and Marine Technology.