Chloroamphenicol-Induced Hemolysis in Caucasian Glucose-6-Phosphate Dehydrogenase Deficiency
Abstract
Three white G6PD-deficient patients suffered severe hemolytic reactions during treatment for typhoid fever with chloramphenicol. Two of these patients were studied when free of infection to determine the hemolytic potential of chloramphenicol in the noninfected G6PD-deficient white person. It was found to be mildly hemolytic under these conditions, suggesting that a drug- disease synergism was primarily responsible for the clinical hemolytic reactions. The febrile state itself, or changes in plasma amino acids accompanying infection, may be responsible for disease-related hemolysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 29, 1971
- Accession Number
- AD0747137
Entities
People
- Charles H. Halsted
- Mohammed Fathy Abdel Wahab
- R. P. Robertson
- Ronald P. Mccaffrey
Organizations
- Naval Medical Research Unit Three