Morphologic Studies of Hepatitis.
Abstract
Particles were found in cases of chronic hepatitis in hepatocellular nuclei, and these were identified as Australia antigen (HB Ag) by its ability to combine with ferritin labelled HB antibody. The relation of HB Ag to hepatitis has been postulated to be related to the response of the host to an antigen composed in large part of the host's own protein. Two animal models were studied. One was galactosamine induced hepatitis, in which the ultrastructural details of orotate protection was investigated, and the second was alpha naphthyliocyanate induced cholestasis, in which the bile acid pattern and the relation of jaundice to the development of peripheral cholestasis were elucidated. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 22, 1972
- Accession Number
- AD0749156
Entities
People
- Fenton Schaffner
Organizations
- Icahn School of Medicine at Mount Sinai