Immune Hemolytic Transfusion Reactions in Monkeys: Activation of the Kallikrein System.
Abstract
Five monkeys were infused with isologous, isoimmune IgG of high hemolytic titer, and five control monkeys received isologous or autologous nonimmune IgG. The former experienced severe intravascular hemolysis, manifested by a fall in hematocrit and a rise in plasma hemoglobin, and disseminated intravascular coagulation (DIC), manifested by a fall in platelet count, fibrinogen, factor V, VIII, and X concentrations and prolongation of thrombin time. The plasma kallikrein system was activated as evidenced by a rise in spontaneous kallikrein activity and a fall in kallikreinogen and kallikrein inhibitor. One monkey demonstrated particularly striking changes with complete disappearance of kallikrein inhibitor and marked decrease in kallikreinogen. Hageman factor (XII) levels also decreased consistently. These changes were associated with sustained arterial hypotension in three of the five animals. Control monkeys had no intravascular hemolysis or DIC, only transient blood pressure changes, and minor fluctuations in the plasma kallikrein system. It is concluded that hemolysis and DIC induced by immune IgG may be accompanied by arterial hypotension activation of the kallikrein system. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1972
- Accession Number
- AD0749453
Entities
People
- C. Elliott Bell Jr.
- Harry Lopas
- Norman I. Birndorf
- Robert W. Colman
- Stanley J. Robboy
Organizations
- United States Army Medical Research Laboratory