Penetration of Pyridinium Oximes into Human Red Blood Cells.
Abstract
Pralidoxime, a water-soluble monoquaternary oxime, penetrates red cells in relatively high concentrations, both in vitro and in vivo. Structurally related bisquaternary oximes, toxogonin and TMB-4, do not enter to an appreciable extent. Penetration is due to the molecular volume and charge of the oxime, rather than to lipid solubility. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1972
- Accession Number
- AD0750113
Entities
People
- Frederick R. Sidell
- Robert I. Ellin
- William A. Groff