Effects of Monomethylhydrazine on Blood and Cerebrospinal Fluid Glucose in Anesthetized Monkeys
Abstract
Plasma and CSF glucose was investigated in fasted, pentobarital anesthetized rhesus monkeys given monomethylhydrazine (MMH) 25 mg/kg i.v. Glucose was determined by the glucose oxidase method. Fasting blood glucose and CSF glucose in mg % averaged 48.8 plus or minus 2.5 (S.E.) and 45.1 plus or minus 2.9 (S.E.) respectively. The CSF/blood ratio of 0.923 is similar to that reported for dogs but differs from the ratio of 0.6 for humans. Following MMH, both blood and CSF glucose increased to 90.6 plus or minus 8.0 and 63.8 plus or minus 5.5 mg % respectively and the CSF/blood ratio decreased to 0.704. Formation of CSF averaged 0.028 and 0.035 ml/min before and after MMH respectively. Convulsions occurred in half the monkeys 120 minutes after MMH, a time when both blood and CSF glucose were elevated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1972
- Accession Number
- AD0751232
Entities
People
- Bennett A. Shaywitz
- Kenneth C. Back
- Marilyn E. George
- William T. Gormley
Organizations
- Air Force Research Laboratory