Cardiac Toxicity of Aerosol Propellants,
Abstract
The fluoroalkane gases used to propel aerosols sensitize the hearts of mice to asphyxia-induced sinus bradycardia, atrioventricular block and T-wave depression, quickly enter the blood of monkeys, cats and dogs after inhalation and, despite adequate oxygenation, have a spectrum of cardiovascular toxic effects; for example, directly depressing contractility in rat, cat, dog and human myocardium and rapidly inducing ventricular arrhythmias in awake or anesthetized monkeys. The relevance of these findings to sudden unexpected death in young people who deliberately inhale these gases, to the widespread use of household and cosmetic aerosols, which most commonly discharge as propellants, Freons 12, 11 and 114, and perhaps, to the increasing uses of other Freons (e.g., the solvent, Freon 113), makes deeper study of this toxicity mandatory. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1971
- Accession Number
- AD0751425
Entities
People
- Willard S. Harris
Organizations
- Air Force Research Laboratory