Halogenated Hydrocarbons and Drug Metabolism: The Effect of Fluorocarbons on Hexobarbital Sleeping and Zoxazolamine Paralysis Times in Mice

Abstract

A screening program has been initiated for the purpose of exploring the possibility that the inhalation exposure of rodents to selected halogenated hydrocarbons may affect enzymes of the hepatic smooth endoplasmic reticulum, the so-called microsomal drug-metabolizing enzymes. The materials of interest to the Air Force which have come under investigation include bromotrifluoromethane, trichlorotrifluoroethane, and dibromotetrafluoroethane. Some work with halothane has also been done for comparative purposes.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1971
Accession Number
AD0751428

Entities

People

  • Ethard W. Van Stee
  • James P. Murphy
  • Kenneth C. Back

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Animal Structures
  • Biomedical Research
  • Cardiac Arrhythmias
  • Chemical Synthesis
  • Chemistry
  • Endoplasmic Reticulum
  • Fire Extinguishers
  • Fire Extinguishing Agents
  • Halogenated Hydrocarbons
  • Hydrocarbons
  • Materials
  • Medical Personnel
  • Metabolism
  • Pharmacology
  • Standards

Readers

  • Fire Suppression Systems Design.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology