Experimental Mutability of Venezuelan Equine Encephalitis Virus. Part 2. Properties of Mutants Induced by Nitrous Acid

Abstract

The changes of characteristics of Venezuelan equine encephalomyelitis virus (VEE) induced by nitrous acid were studied. The treatment of VEE virus by this mutagen resulted in the initiation of mutations affecting the character of pathogenicity, but not mutations affecting only the size of negative plaques were observed. Mutants with lacking or reduced pathogenicity for animals were characterized by small negative plaques, by a low rate of virusemia and by thermolability. Besides these mutants posessed pronounced antigenic and immunogenic characteristics.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1972
Accession Number
AD0752177

Entities

People

  • R. G. Solyanik
  • V. D. Podoplekin
  • Yu. V. Fedorov

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Encephalitis
  • Equine Encephalitis
  • Immunization
  • Inoculation
  • Lagomorphs
  • Materials
  • Mutagens
  • Nitrogen Compounds
  • Resistance
  • Rodents
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Virology (or Medical Virology).