Replication of Infectious Viral RNA in Isolated Mitochondria. I. Penetration of Viral RNA into Mitochondria and Its Effect on Mitochondrial Synthesis

Abstract

It is established that during the incubation of isolated mitochondrias of rat livers with infection RNA of Venezuelan equine encephalomyelitis (VEE), its penetration into mitochondria is noted. Actinomycin D and cell sap stimulated RNA penetration. The distribution of viral RNA in mitochondria subfractions was studied. A considerable content of labelled RNA was detected in fractions of internal membranes and the matrix. In mitochondria infected in this manner, incubation of RNA synthesis was noted, and no marked effect on the synthesis of mitochondria protein was observed.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1972
Accession Number
AD0752191

Entities

People

  • F. I. Ershov
  • L. I. Menshikh
  • O. I. Kiselev
  • O. V. Zaitseva
  • V. S. Gaitskhoki

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animal Structures
  • Arbovirus Infections
  • Biomedical Research
  • Cell Nucleus
  • Cells
  • Incubation
  • Infection
  • Membranes
  • Mitochondria
  • Organelles
  • Rna Viruses
  • Scintillation Counters
  • Traction
  • Venezuelan Equine Encephalomyelitis
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Computer science

Readers

  • Virology (or Medical Virology).