Further Characterization and Species Specificity of Leukocytic Endogenous Mediator (LEM) (36842)

Abstract

A degree of cross species susceptibility was observed on the effects of leukocytic endogenous mediator (LEM) on serum zinc depression and amino acid flux. LEM was shown to be protein in nature, and relatively stable under a wider range of pH and conditions of storage. Although LEM shares several chemical and physical characteristics with endogenous pyrogen (EP), some differences between the chemical properties and species specificity of these two mediators were noted.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1972
Accession Number
AD0753422

Entities

People

  • F. E. Chapple Iii
  • M. C. Powanda
  • R. S. Pekarek
  • R. W. Wannemacher Jr.
  • W. R. Beisel

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Assays
  • Biomedical Research
  • Blood
  • Body Temperature
  • Carboxylic Acids
  • Chemical Properties
  • Citric Acid
  • Depression
  • Diseases And Disorders
  • Infectious Diseases
  • Laboratory Animals
  • Leukocytes
  • Metabolism
  • Molecules
  • Physical Properties

Readers

  • Cardiovascular Physiology
  • Molecular Genetics
  • Pulsed Power and Plasma Physics.