Protection of Skin Against Cercaria Penetration
Abstract
The project was designed to test the hypothesis that skin substantive polymers, and polymers formed within the skin can interfere with the penetration of cercaria of Schistosoma mansoni. Both water-soluble and water-insoluble polymers were applied to skin (mouse tails), and low molecular weight monomers were diffused into skin and polymerized within the upper layers, to form physical or biological barriers. The results obtained indicate that application of highly charged water-soluble polymers (polyethyleneimines) can lead to substantial reduction of cercarial penetration. These materials are skin-compatible, non-toxic, non-flammable, easily applied to large areas of skin, and are commerically available products.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 27, 1972
- Accession Number
- AD0753482
Entities
People
- A. Waldman
- V. R. Usdin