Virus-Host Interactions in Abnormal Cells.
Abstract
A biologically active substance has been concentrated by chemical and physical fractionation from benthic marine algae. When added to the growth medium of a mammalian cell line, it caused micronucleation, amitosis, and multiple cell division. Following metaphase, multiple cytokinesis led to the formation of genetically deficient 'mini cells'. The appearance of binucleate cells in synchronized populations suggested the induction of an amitotic sequence prior to normal metaphase which did not occur. The compound is active at a concentration of 0.01 mg per liter and is available in lyophilized form. Populations of 'mini cells' and micronucleated cells supported development of vaccinia and adenovirus. It is suggested that maturation processes were governed by the viral genome and not the host cell.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 1973
- Accession Number
- AD0755479
Entities
People
- Theodore J. Starr