Primary Irritation Evaluation Program, Study Numbers 51-015-73, 51-017-73, 51-019-73, and 51-020-73.

Abstract

Four candidate repellents were evaluated on New Zealand white rabbits for their potential to cause skin irritation. The data obtained serve as a basis for making recommendations that are intended only for guidance in further entomological testing of the compounds. These recommendations do not constitute approval for testing on human volunteers. The repellents, 1-hexanoyl-4-pipecoline, 1-octanoyl-4-pipecoline, 1-hexanoyl-2-ethylpiperidine, 1-heptanoyl-2-ethylpiperidine (ENT-35633-Ga, ENT-35635-Ga, ENT-35643-Ga and ENT-35644-Ga) produced moderate primary irritation of the intact skin and the skin surrounding an abrasion. These compounds should not be used directly on the skin without a prophetic patch test having been conducted.

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1972
Accession Number
AD0755518

Entities

People

  • Rudy Stine

Tags

DTIC Thesaurus Topics

  • Abrasion
  • Chemical Warfare Agents
  • Chemical Weapons
  • Guidance
  • Irritation
  • New Zealand
  • Nonlethal Agents
  • Nonlethal Weapons
  • Test And Evaluation
  • Volunteers

Readers

  • Toxicology/Environmental Toxicology