Effects of Mannitol and Dextran on Interstitial Pulmonary Edema.
Abstract
Pulmonary interstitial edema in the isogravimetric perfused canine lung produced by venous constriction results in decreased compliance and pulmonary venous PO2, and increased pulmonary capillary pressure. Released of venous constriction is associated with further deterioration in pulmonary venous PO2, and no improvement in lung weight or compliance although PCi returns towards normal. Addition of 15 gms LMS dextran minimizes the fall in PVO2 and shows less perivascular edema microscopically, but does not otherwise differ from untreated controls. In contrast, deleterious effects are noted following addition of 1.5 gms mannitol shown by marked weight gain, increased PCi, decreased PVO2 and decreased compliance. In addition, electron microscopy shows focal endothelial cell damage and more marked perivascular space edema. The adverse effects of mannitol may relate to its smaller molecular weight facilitating entry into the interstitial space. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 12, 1973
- Accession Number
- AD0755705
Entities
People
- Jacqueline J. Coalson
- James R. Mccurdy
- Lazar J. Greenfield
- Michael E. Reif
Organizations
- University of Oklahoma Health Sciences Center