Release of Histamine from Mast Cells by Vasoactive Peptides.
Abstract
The effect of a variety of synthetic pepides on rat mast cells was investigated. Peptides with two or more basic groups were active histamine releasers, while eledoisin, angiotensin I and II, glucagon, and fibrinopeptide A had slight or no activity. The activity of bradykinin analogues increased with the chain length. Des-arginine derivatives of bradykinin did not release histamine. The most potent histamine liberators were substance P and polistes kinin; the activity of the latter one approached that of 48/80. Because histamine could be released by the kinin peptide without disruption of the mast cell membrane, these agents like 48/80, probably stimulate exocytosis of mast cell granules. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 12, 1973
- Accession Number
- AD0755707
Entities
People
- Alice R. Johnson
- Ervin G. Erdoes
Organizations
- University of Oklahoma Health Sciences Center