Red Blood Cell Density and Volume Changes in Men Exposed to Hypobaric Hyperoxia

Abstract

Eight volunteers were exposed to 100% O2 at 258 mm. Hg for 31 days. Blood samples were taken daily, and red cell (RBC) volume distributions were determined by Coulter counter--RBC density distributions, by the method of Danon and Marikovsky. RBC volume distribution varied in a cyclic fashion but exhibited no consistent, significant changes. After 4 to 6 days in the test environment, the RBC populations showed an increase in the proportion of dense cells; and a trend of increasing senescence was evident for the remainder of the exposure period. Postexposure changes indicated the formation of new red cells.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1972
Accession Number
AD0755783

Entities

People

  • Edward C. Larkin
  • William T. Williams

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Analysis Of Variance
  • Blood
  • Blood Cells
  • Cells
  • Data Processing
  • Data Science
  • Distribution Curves
  • Erythrocytes
  • Gaussian Distributions
  • Information Science
  • Measurement
  • Schools
  • Statistical Analysis
  • Statistical Tests

Readers

  • Aerosol Science/Aerosol Physics
  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology