Organotins for Antimalarial Screening
Abstract
It was proposed to prepare for antimalarial screening organotins in four general categories: (1) preparation of a variety of relatively simple organotins for general screening; (2) introduction of organotin groups into quinine its derivatives; (3) introduction of organotin groups into 4- aminoquinoline; (4) introduction of organotin groups into sulfones which had shown some antimalarial activity. It was possible to carry on research on three of these categories. However, successful synthetic results were obtained only in the first of these. A total of forty three compounds was submitted for testing, and test results were returned on thirty six of these. These included: unsaturated fulfones; alkylallyltins; alkylallenyltins; alkylpyridines; bicycloheptyltins; and bis-salicylidenediaminoethane-alkyltin halide complexes. Some showed activity in mice, but were inactive or toxic in chicks; and vice versa. None were active in both, and many were toxic in one or both.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 05, 1973
- Accession Number
- AD0756585
Entities
People
- Henry G. Kuivila
Organizations
- State University of New York at Albany