Kinetic Evidence for a Unique High Affinity Uptake System for Choline in Rat Brain Synaptosomes.
Abstract
Synaptosomes from rat brain accumulate choline by two kinetically distinct processes, a high-affinity uptake system (Km = .000001 M) and a low-affinitysystem (Km = .00009 M). The high-affinity uptake has an absolute requirement for sodium and is associated with considerable formation of acetylcholine. By contrast the low-affinity uptake system has much less dependence on sodium and does not appear to be associated with a marked degree of acetylcholine formation. The high-affinity choline uptake appears to represent choline accumulation selectively by cholinergic neurons. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1973
- Accession Number
- AD0757156
Entities
People
- Henry I. Yamamura
- Louis A. Fedele
- Solomon H. Snyder
- Tommy L. Gardner