Mechanisms of Hemolysis.
Abstract
Erythrocyte damage by surface or wall interaction is accompanied by the release of free 2,3 DPG to the plasma, in greater concentrations than normally exist within the cell, compared to hemoglobin. Similar findings occur after lysis due to shear stress and osmotic forces. Following incubation, 2,3 DPG is rapidly depleted in both control and damaged specimens, and the oxyhemoglobin dissociation curve is shifted to the left to the expected degree. Only after osmotic lysis is RBC ATP concentration substantially depleted, although free plasma ATP is demonstrable following both shear and osmotically induced inuury. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1973
- Accession Number
- AD0758454
Entities
People
- Eugene F. Bernstein
Organizations
- University of California, San Diego