Intrarenal Regulating Mechanisms for Renal Hemodynamics during Shock.
Abstract
A method was developed which allows the quantitative measurement of renin activity in single juxtaglomerular apparatuses (JGA) of the rat kidney. For this purpose a highly purified rat renin substrate was produced and characterized. This method was applied in order to study the changes in JGA renin activity which occur during acute renal failure induced by temporary renal ischemia. The reduction in glomerular filtration rate in the damaged kidneys was associated with a higher JGA renin activity as compared to that of the normal kidney. Together with the finding that Na concentration in the tubular fluid in the macula densa segment of the nephron is elevated in the damaged kidney, these data are consistent with the operation of a feedback control of GFR. These data implicate new methods of treating acute renal failure. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1973
- Accession Number
- AD0762336
Entities
People
- Klaus Thurau
Organizations
- Ludwig-Maximilians-Universität München