Local Immunity to the Diarrhea-Inducing Toxin of the Cholera Vibrio
Abstract
Challenge infection with V. cholerae in the ligated ileal loop of the normal adult rabbit indicated that the unwashed loop was significantly more susceptible than the washed loop. It is suggested that this was due to the potentiating effect of mucin in the former. Such challenge of actively immunized animals in which the local immunity was a function of either antitoxic or complement-dependent vibriocidal antibody showed that both kinds of immunity were protective to ca 2 logs in the washed loop, but no significant protection was observed in the washed loop. This was taken to suggest the primary importance of intraluminal antibody. Comparison of these results with those of challenge with cell-free toxin in which protection appeared to be a function of tissue-contained antitoxic 11S IgA indicated that intraluminal 11S IgA had a complement-independent antibacterial activity as well as antitoxic activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1973
- Accession Number
- AD0762473
Entities
People
- William Burrows
Organizations
- University of Chicago