The Bohr Effect in Chronic Hypercapnia.
Abstract
The study investigates whether the changes in oxygen affinity produced by exposure to 15% CO2, which affects oxygen transport by reducing oxygen delivery at the tissue level, would be compensated by changes in the Bohr effect. The Bohr effect showed a marked increase during chronic exposure to 15% CO2. The effective Bohr effect, which is the additional oxygen released at 50% oxyhemoglobin saturation (P50) when blood is acidified from pH 7.4 to 7.3, was found to be elevated during the periods of greatest respiratory stress. These findings are of interest to personnel concerned with toxicological aspects of increased carbon dioxide exposure as potentially found in Navy submarine and diving environments as well as other hazards which might induce an acidosis such as hyperbaric hyperoxia.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 13, 1972
- Accession Number
- AD0763394
Entities
People
- Arthur A. Messier
- Karl E. Schaefer
Organizations
- Naval Submarine Medical Research Laboratory