The Application of Pattern Recognition to Screening Prospective Anti-Cancer Drugs: Adenocarcinoma 775 Biological Activity Test.
Abstract
A novel application of pattern recognition to the screening of potential anti-cancer drugs is presented. Structural features of 200 drugs previously tested by the National Cancer Institute for activity in the solid tumor adenocarcinoma 755 screening test are input to a master program of pattern recognition methods. The programs were 93.5% accurate in discriminating drugs with positive anti-neoplastic activity versus those with no anti-cancer activity. Extensions to a more rational approach to 'drug design' are also discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1973
- Accession Number
- AD0766504
Entities
People
- Bruce R. Kowalski
- Charles F. Bender
Organizations
- Colorado State University