Experimental Human Exposure to Propylene Glycol Dinitrate
Abstract
Human volunteers were exposed to PGDN vapor at concentrations of 0. 03, 0.1, 0.2, 0.35, 0.5, and 1.5 ppm. Exposure to concentrations of 0.2 and greater produced disruption of the organization of the visual evoked response (VER) and headache in the majority of subjects. Subjects repeatedly exposed to 0.2 ppm for 8 hours on a daily basis developed a tolerance to headache induction, but the alteration in VER morphology appeared cumulative. Marked impairment in balance became manifest after exposure to 0.5 ppm for 6 1/2 hours while 40 minutes of exposure to 1.5 ppm added eye irritation to the list of symptoms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1973
- Accession Number
- AD0766977
Entities
People
- Carl L. Hake
- Jack E. Peterson
- Michael J. Hosko
- Paul E. Newton
- Richard D. Stewart
Organizations
- Medical College of Wisconsin