Effect of Methylprednisolone on the Lethality of Endotoxemic Mice
Abstract
In order to establish a reliable control for E. coli endotoxin studies, the lethality of various doses of endotoxin was tested in mice. Endotoxin (10 mg/kg, i.p. and 30 mg/kg, i.p.) resulted in a lethality of 60% and 87%, respectively. Methylprednisolone given 1 hr before endotoxin increased survival to 75% as compared to the 13% survival of the group which endotoxin alone. Methylprednisolone (30 mg/kg, s.c.) increased survival markedly when given 1 hour before, simultaneous with, and from 1-6 hours after E. coli endotoxin (10 mg/kg, i.p.). Methylprednisolone has both a protective and a therapeutic effect on the survival of mice treated with E. coli endotoxin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 15, 1973
- Accession Number
- AD0767343
Entities
People
- Arthur V. Prancan
- Jiro Nakano
Organizations
- University of Oklahoma Health Sciences Center