BIOMOD Simulation of Pharmacokinetics for Leukemia Chemotherapy,
Abstract
A major problem in leukemia chemotherapy is the delivery of a predicted drug dose to the site of action, for example, the bone marrow. It has been established that the effects of a drug in tissue culture and in animals are comparable if the concentration of a drug at the site of action and the period of its activity are known. Most protocols, however, have been concerned with the drug dose at the point of drug entry, i.e., IV, by mouth, intraperitoneally, etc. A model is required to change the input data into the needed drug concentration at point of action. Bischoff and Dedrick have developed a very reliable compartment model for the blood and for body organ systems. The model parameters are the blood flow through these body compartments, the tissue volumes, and drug metabolism within the compartments. This model and some applications have been programmed in the BIOMOD simulation format. Utilization of the BIOMOD to study drug dose at site of action is summarized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1973
- Accession Number
- AD0768026
Entities
People
- Joseph F. Gross
- Phillip A. Harris
- Thomas L. Lincoln
Organizations
- RAND Corporation