Combined Use of Interferon and Certain Styrylquinolines in Cell Culturing and in Experimental Arbovirus Infection Infection

Abstract

The effect of the combined use of interferon and certain preparations of the styrylquinoline group on the reproduction of the viruses of Venezuelan equine encephalomyelitis (VEE) and Western equine encephalomyelitis (WEE) was studied. The preparations R-29P, R-42P and R-43P in combination with interferon in chicken embryo fibroblast cultures showed antiviral activity in a reduction of VEE and WEE virus titers by 6.6 and 7.5 log, respectively. Preliminary treatment of white mice with WEE virus, followed by two injections of R-42, led to increased protective antiviral activity and to prevention of development of the disease in 60-75% of the test animals, depending on the infectious dose.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1973
Accession Number
AD0768502

Entities

People

  • A. K. Shubladze
  • A. N. Fomina
  • G. A. Galegov
  • N. A. Leonteva
  • Z. V. Idrisova

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arbovirus Infections
  • Arboviruses
  • Biological Factors
  • Biomedical Research
  • Cells
  • Culture Techniques
  • Diseases And Disorders
  • Fibroblasts
  • Infection
  • Interferon
  • Proteins
  • Scientific Research
  • Vaccines
  • Venezuelan Equine Encephalomyelitis
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Virology (or Medical Virology).