Baroreceptor Reflex Response to Phenylephrine and Carotid Occlusion in Monkeys Receiving 1000 Rads Cobalt-60

Abstract

Nine conscious monkeys received phenylephrine and carotid occlusion test of baroreflex function before and after 1000 rads Cobalt-60 exposure (dose rate = 170 rads/min.). During the early postradiation minutes, concomitantly with hypotension and tachycardia, both baroreflex tests revealed depressed sensitivity (diminished blood pressure and heart rate changes). After 8-15 minutes postradiation, the phenylephrine, but not the occlusion test demonstrated a reversal to significant baroreceptor hypersensitivity which persisted 24 hours or more. No failure of the baroreflex mechanisms was suggested.

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Document Details

Document Type
Technical Report
Publication Date
Aug 10, 1973
Accession Number
AD0768921

Entities

People

  • A. W. Neely
  • Alfred Bruner
  • Ernest A. Henderson
  • Gerald K. Weiss

Organizations

  • Lovelace Foundation

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Arteries
  • Blood
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Dose Rate
  • Heart Rate
  • Hypersensitivity
  • Hypotension
  • Materials
  • Observation
  • Radiation
  • Sensitivity
  • Veins

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Nuclear and Radiation Engineering.