Immunologic Investigations of Meningococcal Disease. 1. Group-Specific 'Neisseria meningitidis' Antigens Present in the Serum of Patients with Fulminant Meningococcemia
Abstract
Data presented show that patients with fulminant meningococcemia which resulted in death have a readily detectable level of soluble group- specific meningococcal antigen present in their serum. Patients with meningococcal meningitis and who recovered did not give a positive test for meningococcal antigen under the conditions of the test described. The test is rapid, sensitive and specific for meningococcal group-specific antigens. An important relationship yet to be determined is the threshold level of circulating meningococcal antigen in the serum and the reversibility of the disease process. Preliminary observations made at this laboratory indicate such a level may exist. The rapidity and specificity of the counterimmunoelectrophoresis test for meningococcal antigen should permit its use in studying spinal fluids, as well as serum, for rapid identification of the infecting organism. To date, eight spinal fluids have been examined for Neisseria meningitidis antigen. The counterimmunoelectrophoresis test results all agreed with bacterial isolation and identification.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 05, 1970
- Accession Number
- AD0769365
Entities
People
- Earl A. Edwards