Effects of Hypobaric Hyperoxia on the Development and Activity of Immune Spleen Cells
Abstract
The purpose of this study was to evaluate the effect of intermittent exposure to hypobaric hyperoxic conditions (380 mm Hg and 100% O2) on cellular aspects of resistance to an infectious disease. Mice were immunized against Franciscella tularensis while being exposed to the test environment. Spleen cells from these immunized-exposed donors were transferred to nonexposed recipients that were maintained in a normal ground-level environment. These recipient mice were then challenged with F. tularensis to compare their resistance with that of control animals receiving spleen cells from immunized donors which had not been exposed to the test environment. The reverse was also accomplished by immunizing groups of donor mice maintained at ground level and challenging the recipients (of their spleen cells) that were exposed to the test environment. The results indicate that exposure of the donor animals to hypobaric hyperoxia did not affect the development of cellular immunity but in exposed recipients, the activity of immune cells was impaired.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1973
- Accession Number
- AD0769367
Entities
People
- Jerome P. Schmidt
- Tony D. David
Organizations
- United States Air Force School of Aerospace Medicine