A Statistical Analysis of Indicator-Dillution Curves and an Application to the Real Time Analysis of Dye-Dilution Curves During Cardiac Surgery.
Abstract
Circulatory indicator-dilution curves are used to estimate blood flow and volume, and in certain situations the three-parameter lognormal density function can be employed to represent the first passage time distribution of tracer particles through the system. In this paper the least squares principle is used to develop a procedure for estimating the parameters in the lognormal model. A nonlinear regression program (which computes the least squares estimates) and a graphical estimation technique (that provides starting values) are described. An application of the least squares estimation procedure to the real time analysis of dye-dilution curves--obtained from patients during open-heart surgery--is presented, and an illustrative example is included. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1973
- Accession Number
- AD0769623
Entities
People
- Edward L. Frome
- Evan L. Frederickson
Organizations
- University of Texas at Austin