Radiobiology of Large Animals.
Abstract
Hematologic changes occurring during and after complex sequences of low-dose-rate exposure of sheep to gamma radiation (Cobalt 60) have been evaluated. Erythrocytic values were depressed early in the irradiation sequence, with further gradual depression after cessation of exposure. Leukocytic values decreased in a stepwise fashion during the irradiation sequence, with the patterns of decrease and post-irradiation recovery dependent on the particular parameters of radiation exposure. Studies of bone-marrow cell kinetics in mice receiving single exposures have shown that post-irradiation changes in total cellularity depend on dose rate. Further studies of lethality in sheep irradiated at low dose rates have indicated that a previously developed mathematical model relating exposure parameters to lethality may require modification when the exposure dose rate is of the order of 10 R/hr or higher. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1973
- Accession Number
- AD0770131
Entities
People
- David C. L. Jones
- John S. Krebs
Organizations
- SRI International