Myocardial Performance in Splanchnic Arterial Occlusion Shock.
Abstract
The adverse combined effects of mesenteric ischemia and the subsequently precipitated lethal shock following restoration of mesenteric blood flow have implicated direct or indirect roles of the heart in the pathogenesis of shock. The present experiments were carried out to assay the role of the heart in splanchnic arterial occlusion (SAO) shock. Studies were designed to evaluate the combined effects of SAO shock and diminished coronary perfusion pressure on the performance of a stressed heart. Experiments were carried out on isolated hearts exchanging blood with an intact dog subjected to two hours of splanchnic arterial occlusion. Release of the occlusion did not result in any measurable detrimental effect on the heart: Left ventricular end diastolic pressure and cardiac power were maintained in the normal range at mean aortic pressures (afterloads) between 34-125 mm Hg al all times during the post-occlusion period. DP/dt was elevated, possible as a result of increased coronary blood flow and decreased coronary vascular resistance. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 20, 1973
- Accession Number
- AD0770153
Entities
People
- L. J. Greenfield
- Lerner B. Hinshaw
- Linda T. Archer
- M. R. Black
Organizations
- University of Oklahoma Health Sciences Center