CS: A Study of Carcinogenicity
Abstract
A study of the carcinogenicity of 0-chlorobenzilidenemalononitrile (CS) in animals is reported. The question of carcinogenicity arose because CS has been described as an alkylating agent and some alkylating agents are carcinogens. The study showed no significant increase of lung tumors in A/J strain mice or Sprague-Dawley-Wister rats from exposure to CS to Ct's of 50 and 500 mg min/cu m daily for 20 days (5 days a week for four weeks). Exposure concentrations were about 21 mg/cu m. Total Ct's were, thus, 1.000 and 10,000 mg min/cu m. Such a dose would not increase the incidence of tumors by more than 5% if an extremely large sample of animals were dosed. A rioter in the open would not be expected to recieve a Ct of greater than 10 mg min/cu m and perhaps 1.0 to 2.5 mg min/cu m on the average. Chronic exposure to very low concentrations in an industrial situation could be of greater concern. The data indicate that CS is not a potent carcinogen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1973
- Accession Number
- AD0770365
Entities
People
- Bernard P. Mcnamara
- Duane F. Fore
- Edmund J. Owens
- Harry Rozmiarek
- Roger A. Renne