Effect of Adrenalectomy of Antibody-Forming Cell Production in Animals with a Delayed Type of Hypersensitivity,
Abstract
The present research has studied the effect of a bilateral adrenalectomy on the formation of cells which form an antibody to the corpuscular antigen (sheep erythrocytes) in guinea pigs with a delayed type of hypersensitivity (HDT) to human serum albumin (HSA). The following conclusions were drawn for guinea pigs which have received an adrenalectomy and have been sensitized by human serum albumin in a complete Freund's adjuvant, participation of the regional lymph nodes is prevalent in antibody formation. The adrenalectomy led to a decrease in the absolute and relative number of antibody-forming cells in the lymph nodes and spleen of the animals. When the adrenals were removed it was obvious that the mechanism which regulates the intensity of proliferation of the lymphoid fiber had been destroyed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 12, 1973
- Accession Number
- AD0770937
Entities
People
- T. K. Valueva
- V. F. Chebotarev
Organizations
- National Air and Space Intelligence Center