Effect of Diethylaminoethyl Dextrane on the Antiviral Action of a Complex of Polyinocynic and Polycytidylic Acids in Tissue Culture

Abstract

Using a model of first-trypainized fibroblasts of chicken embryos and RNA-containing virus s of vesicular stomatitis and Venezuelan equine encephalomyelitis, the authors studied the conditions of the stimulating effect of a polycation of diethylaminoethyl dextrane (DEAED) on the antiviral activity of a complex of synthetic polynucleotides, namely polyinocynic and polycytidylic acids. The degree of induction of interferon-formation and suppression of virus reproduction was found to depend on the relative size of the doses of polycation and of the polynucleotide complex, as well as on the method of processing the cells and the time of their contact with the preparations.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1972
Accession Number
AD0770954

Entities

People

  • A. S. Novokhatskii
  • F. I. Yershov

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Acids
  • Arbovirus Infections
  • Biomedical Research
  • Cells
  • Culture Techniques
  • Fibroblasts
  • Interferon
  • Laboratory Animals
  • Materials
  • Mouth Diseases
  • Nucleic Acids
  • Nucleotides
  • Plastic Explosives
  • Proteins
  • Tissue Culture
  • Venezuelan Equine Encephalomyelitis
  • Viruses

Fields of Study

  • Medicine

Readers

  • Virology (or Medical Virology).