Inhalation Therapy with Antibiotics
Abstract
Many problems are created in the antibiotic therapy of bacterial exacerbation in cases of chronic bronchitis. One of these problems, nodoubt, is the recidivism, which invariably follows the end of the antibiotic effect within a period of time. The non-purulent interval betweentwo recidivisms is called the relapse rate. On the one hand, there are close relations between the relapse rate and the functional state ofthe bronchial mucous tissues which exhibit powerful defensive mechanisms in the healthy state. However, the mucous membranes are damaged functionally and morphologically to such an extent in the advanced state of the disease that they are no longer capable of providing natural resistance against subsequent reinfection. On the other hand, there are interesting relations between the relapse rate and the composition, dose, and administration mode of the antibiotic used. Thus, the infection-free interval provides some information on the economic aspects of a given preparation. The relapse rate is shortest after treatment with tetracyclin preparations; it is much longer after treatment with chloramphenicol, cephalosporin, and ampicillin; for a long time it has been the most impressive after administration of the combination preparation Trimethoprim + Sulfamethoxazol. It is now superseded by Amoxycillin. There is an obvious relationship between the length of the infection-free interval and the dose given (bactericidal bacteriostatic).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 19, 1973
- Accession Number
- AD0771236
Entities
People
- H. Buergi
Organizations
- United States Army Medical Research Institute of Infectious Diseases