Pharmacokinetic Studies of Sputum, Serum, and Urine Concentration of Gentamycin after Aerosol Inhalation,
Abstract
Absorption studies of gentamycin were conducted. Four patients were administered the antibiotic by mouth, and 24 as an aerosol inhalation. The gentamycin concentrations in the sputum and serum were determined at intervals up to four hours, and in the urine up to 24 hours, following the inhalation of 80 mg by 20 patients. No gentamycin could be detected in the serum after oral adminstration. High levels were found in the sputum within the first three hours. The serum concentration corresponded to the sputum concentration levels; they were generally low, being a hundredfold less than the sputum levels, with a maximum value of 0.7 microgram. The total recovery in the urine was correspondingly low, with an average gentamycin recovery of less than 5.2%. Investigations indicate it to be unlikely that any additive effect might arise from combined oral and inhalation administration, and thus that there might be increased incidence of side effects. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1973
- Accession Number
- AD0771899
Entities
People
- H. Regula
- O. Wieser
- P. Naumann
- U. Kleinhuber
- W. Wundt