Disappearance of Tri-, Di-, and Monoglycerides From the Circulation of Dogs.
Abstract
Artificial emulsions of cotton seed oil were rapidly infused intravenously into unanesthetized dogs. Arterial blood samples were withdrawn at timed intervals and plasma volume and plasma levels of tri-, di-, and monoglycerides were quantitatively measured. Analyses of the data thus obtained indicated a biphasic disappearance of a triglyceride load from the bloodstream. Phase I consisted of an initial rapid disappearence of about 35% of the triglyceride. Four to eight minutes later, the disappearance decreased to a linear rate inversely related to the ratio of triglyceride initially removed to the quantity infused. Prior treatment with heparin increased the initial disappearance rate, whereas protamine had no effect. Hepatectomy reduced the Phase II disappearance rate by one-half. Infused di- and monoglycerides disappeared more rapidly than triglycerides. The absence of an altered initial triglyceride uptake rate following hepatectomy and a prolonged initial rate upon heparin infusion suggests that this rapid uptake was mediated largely by extra-hepatic mechanisms. A three phase pattern of triglyceride uptake from the circulation following Lipomul infusion is proposed and discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1973
- Accession Number
- AD0771935
Entities
People
- E. Wayne Askew
- Joseph B. Vacca
- Mark Nugent
- Paul P. Waring
- Robert M. Nims