Study of Virulence and Immunogenic Properties in Recombinants of the Plague Microbe: Imparted Episomal Polyresistance to Antibiotics as a Result of Conjugation with a Strain of Intestinal Bacillus Possessing the R Episome,
Abstract
Recombinants resistant to streptomycin, chloramphenicol, and tetracycline were obtained possessing the high virulence and immunogenic properties of the receptor strain of plague microbe (Pasteurella pestis). Conjugation of a less virulent plague microbe strain with polyresistant E. coli resulted in a loss of virulence due to genetic heterogeneity of the receptor strain rather than to the effect of the R-episome received. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 20, 1973
- Accession Number
- AD0772447
Entities
People
- P. I. Anisimov
Organizations
- United States Army Foreign Science and Technology Center