The Influence of 3,5-Diethylhydantoin upon Survival During Acute and Chronic Hypoxia
Abstract
The median survival times of rats decompressed within five minutes to a barometric pressure of 160 mm Hg (33.5 mm Hg PO2) were significantly increased (P less than .05 and P less than .02) in two groups of 15 rats each pretreated with 150 mg/kg body wt 3,5-diethylhydantoin (DH); rats pretreated with 50 mg/kg of the drug did not differ from controls. Maximum swimming times of 15 rats exposed to a PO2 of 77 mm Hg and a water temperature of 35C tended to be longer following pretreatment with 50 mg/kg DH (P less than .10). Sixteen of 20 saline-injected controls survived 11 days of continuous exposure to a PO2 ranging from 37 to 49 mm Hg, compared with 10 of 20 animals treated daily with 50 mg/kg and 7 of 20 treated with 150 mg/kg DH. The drug-treated animals showed more abnormal pathology than controls. It was concluded that although DH treatment may result in an increase in survival time during acute hypoxia, its apparent toxicity with repeated use in a hypoxic environment precludes its consideration in U.S. Air Force operations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1973
- Accession Number
- AD0772695
Entities
People
- Gene A. Dixon
- John M. Swann
- Robert G. Streeter
- William E. Pepelko
Organizations
- United States Air Force School of Aerospace Medicine