Failure of Methylprednisolone to Protect Lead-Sensitized Rats against Endotoxin

Abstract

The administration of lead acetate (PbAc2) sensitizes both rats and subhuman primates to minute amounts of bacterial endotoxin. The mechanism of this sensitization has not been defined, although it has been suggested that alterations in either the degradation of endotoxin, or in carbohydrate metabolism, may be important. Glucocorticoids are demonstrably effective in protecting normal animals against endotoxin. The purpose of the present investigation was to determine if this was also the case in lead-sensitized animals.

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Document Details

Document Type
Technical Report
Publication Date
Jun 27, 1973
Accession Number
AD0773679

Entities

People

  • James L. Wise
  • Lutz A. Kiesow
  • Robert B. Jones

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Carbohydrate Metabolism
  • Carbohydrates
  • Commerce
  • Degradation
  • Endotoxins
  • Hemorrhagic Shock
  • Infection
  • Lethal Dosage
  • Lethality
  • Metabolism
  • Navy
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Strategic Security Studies
  • Toxicology/Environmental Toxicology